Description
CAS : 9012-00-4
Product description :
Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation and DNA stabilization. They may allow for denser packaging of DNA in spermatozoon than histones, but they must be decompressed before the genetic data can be used for protein synthesis. Genes that are essential for early embryonic development are still bound to ordinary histones, comprising about 4 percent of the DNA in spermatozoons.
Medical Uses:Protamine is used in cardiopulmonary bypass surgery to neutralize the anti-clotting effects of heparin as well as to increase pulmonary artery pressure and decrease peripheral blood pressure, myocardial oxygen consumption, cardiac output, and heart rate.
