Description
[ CAS No. ] 79902-63-9
[ Synonyms ] (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl 2,2-dimethyl-butanoate
[ Molecular Formula ] C25H38O5
[ Molecular Weight ]418.57
[ Appearance ] White crystal powder
[ Density ] 1.11 g/cm3
[ Melting Point ] 139ºC
[ Boiling Point ] 564.9ºC at 760 mmHg
[ Flash Point ] 184.8ºC
[ Assay ] 98% min (HPLC)
[ Function&Application ]
(1) The primary uses of simvastatin are for the treatment of dyslipidemia and the prevention of cardiovascular disease.
(2) It also can used for the patient with coronary heart disease.
About Simvastatin
To control the blood cholesterol levels and prevent cardiovascular disease.
Simvastatin is a hypolipidemic drug used with exercise, diet, and weight-loss to control elevated cholesterol, or hypercholesterolemia. It is a member of the statin class of pharmaceuticals.
Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 µM).
